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Factors which can lead to protein denaturizing

What are various factors which can lead to protein denaturizing?

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Protein denaturizing can be caused by the temperature variation, pH change, and modifications in the concentration of surrounding solutes and by some other processes. Most of the proteins are denatured subsequent to certain elevation of temperature or whenever in very acid or very basic solutions. This is one of the major reasons, why it is essential for the organisms to stay stable pH and adequate temperature.   

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