Digestion of Nucleic acids:

Digestion in mouth and stomach:

In the mouth there are no enzymes to digest nucleic acids.

The extremely acidic medium in the stomach destabilizes the nucleoprotein structure and the proteolytic enzymes break down them into nucleic acids and proteins.

Digestion in duodenum:

Pancreatic juice consists of 2 enzymes that are ribonuclease and deoxylribonuclease which can hydrolyze the nucleic acids to mononucleotides.

Relies on the site of action, nucleases can be either endonuclease which attacks the interior linkages or exonuclease that which attacks the terminal linkages.

The intestinal juice or succus entericus consists of the following two enzymes which digest nucleic acids.

a. Nucleotidases which hydrolyze nucleotides to nuclosides and phosphoric acid.
b. Nucleosidases which hydrolyzes the nucleosides to their particular sugars and bases.

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