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Relation between thyroid and hypophysis

Describe briefly the relation between thyroid and hypophysis?

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Hypophysis secretes TSH, thyroid-stimulating hormone. This hormone hastens secretion of thyroid hormones (thyroxine and triiodothyronine, T3 and T4).

When the plasma concentration of thyroid hormones is high this detail is detected by hypothalamus and by hypophysis and this gland decrease the TSH secretion. When the thyroid hormone levels are low TSH secretion raises. It is therefore a negative feedback.

Injuries of hypophysis that cause TSH hyposecretion (for illustration, in case of tissue destruction) hypersecretion (in case, e,g., of excessive cell proliferation or cancer) can alter the functioning of thyroid gland overall.

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