Concentration of drugs in human plasma

Question

Explain how concentration of the drugs in human plasma is defined?

Answer 1

Some of the drugs bind extensively to the plasma proteins ( Warfarin binds 99%) however others have virtually no binding.

Extraction depends upon the kind of drug - there exist several standard methods for basic, acidic, and the neutral drugs - and, indeed, some drugs require some specific extraction techniques.

It is significant for you doing the bioequivalence studies to exactly know the proportion of drug extracted however such controls are again specific for every drug and use the specific marker compounds.