How lncrna knockdown is done


Problem:

I don't work at the wet lab and don't know all the details about the knockdown techniques.

Required:

Question 1: How lncRNA knockdown is done?
For example - you have lncRNA that is functional in the nucleus.

Question 2: How is it possible to do knockdown using iRNA if interference happens only in the cytoplasm?
Please explain in detail.

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Biology: How lncrna knockdown is done
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