Case study of gene expression analysis

The paper by Golub et al. that was the focus of the second part of the BioConductor practical was the first analysis of its kind, demonstrating that gene expression analysis could potentially be used to classify leukaemia sub-types. Since its publication in 1999 there has been considerable interest in developing this approach for diagnostic use and a paper about this, published in Blood in 2002, and provided, is the focus for this assignment.

In this paper, Mary Ross and her colleagues at St Jude’s Children’s Research Hospital in Memphis, performed gene expression analysis on a larger cohort of 155 leukaemia cases, from five different sub-types. While the paper by Golub showed that it was possible to broadly classify leukaemia with this kind of analysis, this later paper demonstrated that even closely related sub-types have very distinct gene expression signatures.
The aim of this assignment is to reproduce the analysis of the data set described in the paper by Ross et al. You are provided with all of the raw Affymetrix data files that were used in the original analysis, and the experiment description files that define which samples belong to the training and test data sets. You will be expected to use a machine learning approach to classification of the data, perform hierarchal clustering on the data, and identify a sub set of genes whose expression defines the data classes.

   Related Questions in Financial Accounting

  • Q : Partner Reflection HRD Programs If you

    If you are working with a partner for your assignment, please answer the following questions individually and submit your paper separately.

    1. Why did you want to work together?

    2. How did you di



  • Q : Accounting Required parts are clearly

    Required parts are clearly describes at the end of the questions and additional resource contains the journal article related to question three.. Approx 2000 word assignment.. First Question is of not more than 1000 words to make memorandum and its example is given at end of assignment and require

  • Q : Benefit of Electronic Funds Transfer

    Illustrate the benefit of Electronic Funds Transfer?

  • Q : What is Corporate Social Responsibility

    Corporate Social Responsibility directly states that every company is responsible towards the society and the environment. So this is a duty of every company to create eco-friendly new products. In the current scenario when the fuel prices are increas

  • Q : Computing cross-rate matrix Compute

    Compute cross-rate matrix for French franc, Japanese yen, German mark, and the British pound. Utilize most recent European term quotes in order to compute the cross-rates in order that the triangular matrix result is same as that of the portion above diagonal in Exhib

  • Q : Advantage of Historical Cost in

    What is the advantage of Historical Cost in Decision Making?

  • Q : Describe JOC in accounting Describe JOC

    Describe JOC in accounting?

  • Q : How Eurocurrency is formed Explain how

    Explain how the Eurocurrency is formed.

  • Q : Relative and absolute purchasing power

    Explain about the purchasing power parity, both the relative and absolute versions. List the things which results in the deviations from purchasing power parity?